About Us
Small molecule membrane interaction
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Protein folding
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In our laboratory we aim to investigate biophysically tractable yet biologically interesting systems, using (mostly) spectroscopic and imaging tools. Our recent focus has been on two problems: protein misfolding/aggregation, and vesicular neurotransmission. Both of these interface with the phenomenon of amyloid-induced neuro-degeneration.
Alzheimer’s Amyloid beta is a small peptide, and therefore expected to be more tractable at a molecular level compared to typical proteins. Yet it is uniquely interesting in the biological context. We have developed single molecule level fluorescence tools specifically suited for studying amyloid misfolding and aggregation. On the other hand, vesicular neurotransmission is a multifaceted phenomena and therefore difficult to simplify beyond the level of single neurons. However, monoaminergic vesicles can be tracked with unique label-free imaging techniques that we have developed in the lab. We hope that a combination of these two techniques, together with other tools, will help us uncover the fundamental mechanisms underlying protein misfolding, aggregation and toxicity. The work described here, undertaken in the last few years, involve different aspects of these themes. In addition, development of biophotonic instrumentation and methodology has been a frequent offshoot of this work in the lab.
Alzheimer’s Amyloid beta is a small peptide, and therefore expected to be more tractable at a molecular level compared to typical proteins. Yet it is uniquely interesting in the biological context. We have developed single molecule level fluorescence tools specifically suited for studying amyloid misfolding and aggregation. On the other hand, vesicular neurotransmission is a multifaceted phenomena and therefore difficult to simplify beyond the level of single neurons. However, monoaminergic vesicles can be tracked with unique label-free imaging techniques that we have developed in the lab. We hope that a combination of these two techniques, together with other tools, will help us uncover the fundamental mechanisms underlying protein misfolding, aggregation and toxicity. The work described here, undertaken in the last few years, involve different aspects of these themes. In addition, development of biophotonic instrumentation and methodology has been a frequent offshoot of this work in the lab.
NEWS• Mr. Arpan Dey has received Mihir Chowdhury Fellowship Award in FCS 2021, IISER Thiruvananthapuram and RGCB
• Mr. Ankur Gupta has received Mihir Chowdhury Fellowship Award in FCS 2019, TIFRH. • Mr. Simli Dey has received Medhavini Hosur Memorial Best Poster Award, 2019 in TAAC TIFR Chemistry Meet, 2019. • Mr. Vicky Vishvakarma has received Best Poster Award in IBS 2019, IISER Kolkata • Ms. Simli Dey has received Biophysical Society Meeting Travel Award, 2019 • Mr. Anirban Das has received Medhavini Hosur Memorial Best Poster Award, 2018 in PAN-TIFR Chemistry Meet, 2018. • Mr. Ankur Gupta has attended Bio-AFM Summer School, 2018 in Japan • Dr. Bappaditya Chandra has received best thesis award in TIFR, Mumbai, 2018. • Dr. Suman Nag has joined in Myo Kardia Inc., San Francisco, USA • Barun Kumar Maity has received best poster award in the FCS 2017, IIT G. • "Best Poster" in IDP, 2017: Barun Kumar Maity, Simly Dey and Bappaditya Chandra have received best poster award in the international conference IDP 2017, IISER Mohali. • "Best Poster" in Biophysical Society Annual Meeting: Bappaditya Chandra got the best poster award (in the category: Intrinsically Disorder Proteins) in the Biophysical Society Annual Meeting, New Orleans, 2017. |
Events• FCS 2021, National Workshop on Fluorescence and Raman Spectroscopy: Nov 29-Dec 4, 2021, IISER Thiruvananthapuram and Rajiv Gandhi Centre for Biotechnology
• FCS 2020, National Workshop on Fluorescence and Raman Spectroscopy: Dec 7-12, 2020, IIT Bombay • FCS 2019, National Workshop on Fluorescence and Raman Spectroscopy: Dec 16-21, 2019, TIFR Hyderabad. • FCS 2018, National Workshop on Fluorescence and Raman Spectroscopy: Nov 12-17, 2018, JNU, New Delhi. • Biophysics Paschim: Tuesday, 28th of March, 2017, TIFR, Mumbai. |
ContactLab :
D-304, Biophotonics Lab. Department of Chemical Sciences,TIFR, Mumbai-400005 Tel No: +912222782716 Prof. Maiti's Office: D-427, Biophotonics Lab. Department of Chemical Sciences,TIFR, Mumbai-400005 Tel No: +912222782539 Student Office: D-308, Biophotonics Lab. Department of Chemical Sciences,TIFR, Mumbai-400005 Tel No: +912222782605 |
